Posts Tagged ‘opioid’
Alkermes Announces Positive Results For Phase 1 Study Of New Drug Candidate For Treatment Of Opioid-Induced Constipation
Alkermes, Inc. (NASDAQ: ALKS) announced positive topline data from a phase 1 clinical study of ALKS 37, an orally active, peripherally-restricted opioid antagonist with potential to block the effects of opioid agonists on gastrointestinal motility, commonly referred to as opioid-induced constipation (OIC)…
In Chronic Pain Patients, Higher Opioid Dose Linked To Overdose Risk
More and more Americans with chronic pain not caused by cancer are taking medically prescribed opioids like Oxycontin (oxycodone) and Vicodin (hydrocodone). The January 19 Annals of Internal Medicine features the first study to explore the risk of overdose in patients prescribed opioids for chronic noncancer pain in general health care…
Higher opioid dose linked to overdose risk in chronic pain patients
More Americans are taking prescribed opioids like Oxycontin long-term for chronic noncancer pain. This study sheds light on the national epidemic of opioid overdose. It is the first to explore the risk of overdose in patients prescribed opioids for chronic noncancer pain in community practice. Researchers link the risk of opioid overdose to prescription use.
Study Reveals Predictors Of Long-term Opioid Use For Back Pain
Despite limited evidence of long-term success in using opioid pain medications for chronic low back pain, opioid prescribing has increased in recent years for back pain and other non-cancer pain indications. The implications are controversial as published studies provide little evidence indicating which patients will benefit from long-term opioid treatment…
Deaths from opioid use have doubled; five-fold increase in oxycodone deaths
Deaths from opioid use in Ontario, Canada, have doubled since 1991 and the addition of long-acting oxycodone to the drug formulary was associated with a 5-fold increase in oxycodone-related deaths, a new study finds. Most of these additional deaths were accidental.
Adolor Corporation Initiates Clinical Testing In Opioid Bowel Dysfunction Program
Adolor Corporation (NasdaqGM:ADLR) announced the initiation of clinical testing of ADL7445, its proprietary, oral mu opioid receptor antagonist for the treatment of Opioid Bowel Dysfunction (OBD). The Phase 1, single ascending dose trial in healthy volunteers will assess safety and tolerability of the compound and will be followed by a multiple ascending dose study in early 2010…
Alkermes Announces Initiation Of Phase 1 Clinical Study Of ALKS 37 For The Treatment Of Opioid-Induced Constipation
Alkermes, Inc. (NASDAQ: ALKS) announced the initiation of a phase 1 clinical study of ALKS 37, an orally active, peripherally-restricted opioid antagonist with potential to block the opioid agonist effects on gastrointestinal motility, commonly referred to as opioid-induced constipation (OIC).
Newly Published Clinical Data Shows Caldolor(R) (Ibuprofen) Injection Reduces Opioid Use While Improving Pain Relief In Post-Operative Patients
Cumberland Pharmaceuticals Inc. (Nasdaq: CPIX) announced that its Phase III study on intravenous ibuprofen as a post-operative analgesic was published in Volume 31, Number 9 of the peer-reviewed journal Clinical Therapeutics, distributed in October. The study concludes that patients emerging from orthopedic and abdominal surgeries required less narcotic and experienced less pain with 800 mg of intravenous ibuprofen every six hours compared to morphine alone.
A New Service For Health Care Providers Who Prescribe Methadone To Treat Chronic Pain Or Opioid Addiction
A new service for health care providers prescribing methadone to treat chronic pain or opioid addiction — the Physician Clinical Support System for Methadone (PCCS-M) — opens this week with a mechanism to connect prescribers of methadone with experienced clinicians for one-to-one mentoring regarding the use of this medication.
Pain Relief Only One Motive For Opioid Use Among High School Seniors
Taking opioid drugs without a prescription appears relatively common among high school seniors, according to a report in the August issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals. The most common reasons survey respondents gave for taking the medications included relaxation, feeling good or getting high, experimentation and pain relief.
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