Posts Tagged ‘induced’
Alkermes Announces Positive Results For Phase 1 Study Of New Drug Candidate For Treatment Of Opioid-Induced Constipation
Alkermes, Inc. (NASDAQ: ALKS) announced positive topline data from a phase 1 clinical study of ALKS 37, an orally active, peripherally-restricted opioid antagonist with potential to block the effects of opioid agonists on gastrointestinal motility, commonly referred to as opioid-induced constipation (OIC)…
Flu-Induced Stress Response Is Critical For Resistance To Secondary Infection
A new study reveals how infection with the influenza virus impacts the way that the immune system responds to subsequent infections. The research, published by Cell Press in the February 18th issue of the journal Cell Host and Microbe, provides a new understanding of the physiological and pathological consequences of the flu…
Teriparatide Outperforms Alendronate In Treating Steroid-induced Osteoporosis
A recent study determined glucocorticoid-induced osteoporosis (OP) is now treatable with Teriparatide, a synthetic form of the human parathyroid hormone. Researchers found patients with glucocorticoid-induced OP who were treated with teriparatide for 36 months had a greater increase in bone mineral density and fewer new vertebral fractures than those treated with alendronate.
Alkermes Announces Initiation Of Phase 1 Clinical Study Of ALKS 37 For The Treatment Of Opioid-Induced Constipation
Alkermes, Inc. (NASDAQ: ALKS) announced the initiation of a phase 1 clinical study of ALKS 37, an orally active, peripherally-restricted opioid antagonist with potential to block the opioid agonist effects on gastrointestinal motility, commonly referred to as opioid-induced constipation (OIC).
It’s Not All In Your Head: Descending Neural Mechanisms Of Placebo-induced Pain Control
A new study reveals that when it comes to pain control, the “placebo effect” involves evolutionarily old pain control pathways in the human brainstem, the part of the brain that is continuous with the spinal cord. The research provides fascinating mechanistic insight into how and why simply expecting that a treatment will reduce pain can act as an effective analgesic.
Discovery Of Descending Neural Mechanisms Of Placebo-Induced Pain Control Means “It’s Not All In Your Head”
A new study reveals that when it comes to pain control, the “placebo effect” involves evolutionarily old pain control pathways in the human brainstem, the part of the brain that is continuous with the spinal cord. The research, published by Cell Press in the August 27th issue of the journal Neuron, provides fascinating mechanistic insight into how and why simply expecting that a treatment will reduce pain can act as an effective analgesic.
Opioid-Induced Hibernation Protects Against Stroke
Using an opioid drug to induce a hibernatory state in rats reduces the damage caused by an artificial stroke. Researchers writing in the open access journal BMC Biology have shown that those animals put into the chemical fugue suffered less behavioral dysfunctions after a period of cerebral artery blockage than control rats.
Study Offers New Insights Into Morphine-Induced Tolerance And Increased Pain Sensitivity
A study published in the June issue of Anesthesiology has shown that a drug metabolite of the opioid morphine may be a key factor in the paradoxical increased sensitivity to pain caused by chronic morphine use. For the first time, this metabolite (called morphine-6 glucuronide, or M6G) was shown to act independently of the pain receptors typically targeted during morphine administration. The study, which was led by Albert Dahan, M.D., Ph.D.
New Section On Opioids And Opioid-Induced Constipation
Medical News Today has created a new medical channel, called All About Opioids and Opioid-Induced Constipation (OIC). Opioids are a class of drugs that are frequently prescribed for treating pain. They include such medications as morphine, codeine, oxycodone and methadone are opioids.
Electroacupuncture Protects Acetylsalicylic Acid-Induced Acute Gastritis In Rats
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as anti-inflammatory and analgesic agents. However, they often cause gastrointestinal injury in gastric lesions by inhibiting COX (cyclooxygenase) and detailed mechanism remains unclear. Thus, effective strategies are required to protect the gastrointestinal mucosa. A research article published on February 28, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr.
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