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Prenatal alcohol exposure can alter the brain’s developing pain regulatory system

Prenatal alcohol exposure is widely known to impair brain development in exposed offspring. Rodent studies have shown that developmental deficits in newborns related to altered levels of a brain chemical called serotonin, leading to subsequent alterations in patterns of neonatal acute pain responses and/or hypothalamic-pituitary-adrenal stress reactivity. New findings show a “blunted response” to an acutely painful event in alcohol-exposed human newborns, indicating that prenatal alcohol exposure may alter the brain’s developing pain regulatory system.

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